Nanoparticles in complex biological environments

In the last decade a lot of effort has been dedicated to elucidate the impact of physicochemical properties of nanoparticles, such as their size, surface charge, hydrophobicity or shape on the subsequent cellular interaction, which is routinely assessed in in vitro systems. One major aspect that has been neglected in the past refers to the aggregation behavior of nanoparticles in the biological environment. Aggregation is a phenomenon that can occurr in electrolyte and protein rich environments (e.g. cell culture media) and (in a non-controlled situation) results in ill-defined systems. The overarching fundamental question to be answered is how nanoparticles behave in biological fluids and how this behavior can be related to nanoparticle-cell interaction, described by cellular uptake and cell response.

Principal investigator

Involved people

External partners

Dr. Marc Obiols-Rabasa

Physical Chemistry, University of Lund, Sweden

Prof. Peter Schurtenberger

Physical Chemistry, University of Lund, Sweden


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