Nanoparticle Dosimetry

With robust nanoparticle characterization, we study how nanoparticle physicochemical characteristics and laboratory methodology influences the outcome of cellular assays.

The turn of the century saw a rise in the amount of research reporting the use of nanomaterials for biomedical purposes (e.g. implant coatings, imaging contrast agents, drug delivery systems, and hyperthermia mediators). However even with a dramatic surge in the number of investigational reports, there is highly variable success translating these nanomedicines into the clinic. This gap in translational success is in part due to difficulty understanding and controlling the tie between nanomaterial physicochemical properties and the biological response. Furthermore, there are widespread inter-laboratory differences in nanoparticle characterization, laboratory methodologies, and bio-analytical assays. This leads to difficulty interpreting and comparing in vitro and in vivo data.

This project is focused on how different parameters such as nanoparticle physicochemical properties (e.g. size, surface charge, surface coating), and laboratory methodology can impact the dose of nanoparticle delivered to cells in vitro. Furthermore, we will attempt to model how these parameters can effect in vitro nanoparticle behavior, and study how these different factors influence cellular response.

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Adolphe Merkle Institute - Chemin des Verdiers 4 - CH-1700 Fribourg - Phone +41 26 300 9254