CH-1723 Marly 1
|Phone:||+41 26 300 9517|
|Fax:||+41 26 300 9624|
Growing up in Perthshire, Scotland, Martin showed a keen interest in biology from an early age. Along with the desire to constantly be active, Martin began his undergraduate degree in 2000, enrolling in the discipline of Sport and Exercise Science at Napier University, Edinburgh. Before graduating with first class honours in 2004, Martin had already begun to get a sense for immunology, toxicology and molecular biology through his activities in his final year research projects. This manifested itself further with the opportunity to study for a PhD in nanotoxicology under the guidance of Professor Vicki Stone. Martin graduated with his PhD from Edinburgh Napier University in 2008 and immediately moved to Switzerland to embark upon his first post-doctoral position in the laboratory of Professor Peter Gehr at the University of Berne. During this period, Martin formed a productive collaboration with Dr. Barbara Rothen-Rutishauser. Since 2010, after the retirement of Prof. Gehr, Martin has continued his collaboration with the Rothen-Rutishauser group, now being a senior researcher in the BioNanomaterials group at the Adolphe Merkle Institute under the guidance of Professor Rothen-Rutishauser and her co-chair, Professor Alke Petri-Fink. Martin is predominantly interested in the effects that nano-objects may elicit upon the cellular signaling pathways within mammalian and pro-karyotic cells, although he is also a keen investigator of the key screening strategies of nano-objects regarding their inherent safety when intentionally used within a range of applications. His constant thirst for further knowledge regarding the immunological and genotoxicological aspects of nano-objects is a further highlight of his research interests, together with a new motivation to form novel bionanomaterials that could promote the advantages of nano-objects/nanomaterials whilst concomitantly reducing their potential risk towards human health. Since 2006, Martin has contributed to 50 scientific manuscripts, including numerous original articles, extensive reviews and book chapters in the field of nanotoxicology. In addition, Martin acts as a reviewer for a range of high-impact journals and is an editorial board member for the journals ‘Particle and Fibre Toxicology’, ‘Fibres’ and ‘Journal of Translational Toxicology’. Furthermore, Martin reviews for different national and international funding bodies, regularly attends both national and international conferences within the field, and lectures to post-graduate students on the topic of nanotoxicology.
Biological impact of nanocellulose
"Nanoparticle-lung interactions and their potential consequences to human health"
Bio-Nanotechnology: A revolution in Food, Biomedical and Health Sciences 2013.
"Nanomaterial and the human lung: What is known and what must be deciphered to realise their potential advantages?"
Swiss Medical Weekly 2013, published.
"Efficiency and efficacy of using a sophisiticated 3D in vitro system of the human epithelial airway barrier to gain insight into the hazard posed by nanomaterials"
Toxicology Letters 2013, 146–147.
"Bioavailability of Silver-Nanoparticles and -ions: From a chemical and biochemical perspective"
Journal of the Royal Society Interface 2013, 87.
"Risk assessment of released cellulose nanocrystals-mimicking inhalatory exposure"
Journal of Physics: Conference Series 2013. [Link]
"Gold nanorods: Controlling their surface chemistry and complete detoxification by a two-step place exchange"
Angewandte Chemie International Edition 2013, 52 (7), 1934–1938. [Link]
"Nanomaterials and the human lung: What is known and what must be deciphered to realise their potential advantages?"
Swiss Medical Weekly 2013, 143, w13758. [Link]
"Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro"
Nanoscale 2013, 5 (9), 3723–3732. [Link]
"Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface"
Particle and Fibre Toxicology 2013, 10 (1), 11. [Link]
"Studying the oxidative stress paradigm in vitro: A theoretical and practical perspective"
Methods Mol. Biol. 2013, 1028, 115–133. [Link]
"Investigating the interaction between nano-objects and bacteria: Can it provide an insight into nano-object mutagenicity?"
"Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria"
Nanotoxicology 2012, 1–12.
"Carbon nanotubes: An insight into the mechanisms of their potential genotoxicity"
Swiss Medical Weekly 2012, 142, 142. [Link]
"Cerium dioxide nanoparticles can interfere with the associated cellular mechanistic response to diesel exhaust exposure"
Tox Letters 2012, 2012 (2), 218–225. [Link]
"Methods for understanding the interaction between nanoparticles and cells"
Methods Mol Biol 2012, 926, 22–56. [Link]
"Investigating the potential for different scooter and car exhaust emissions to cause cytotoxic and (pro-)inflammatory responses to a 3D in vitro model of the human epithelial airway"
Tox Env. Chem. 2012, 94 (1), 164–180. [Link]
"Pulmonary surfactant coating of multi-walled carbon nanotubes (MWCNTs) influences their oxidative and pro-inflammatory potential in vitro"
Particle and Fibre Toxicology 2012, 9, 9:17. [Link]
"Quantum Dots: An Insight and Perspective of Their Biological Interaction and How This Relates to Their Relevance for Clinical Use"
Theranostics 2012, 2 (7), 668–680. [Link]
"Human epithelial cells in vitro – Are they an advantageous tool to help understand the nanomaterial-biological barrier interaction?"
EuroNanoToxLetters 2012, 4 (1), 1–20. [Link]
"Effects of flame made zinc oxide particles in human lung cells - a comparison of aerosol and suspension exposures."
Particle and Fibre Toxicology 2012, 9, 33. [Link]
"Amino covalent binding approach on iron oxide nanoparticle surface: Toward biological applications"
Colloids and Surfaces A: Physicochemical and Engineering Aspects 2012, 415, 98–104. [Link]
"Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria."
Nanotoxicology 2012. [Link]
"Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices"
Nanotoxicology 2011, 5 (1), 1–11. [Link]
"A brief summary of carbon nanotubes science and technology: A health and safety perspective."
ChemSusChem 2011, 4 (7), 905–911. [Link]
"Laser scanning microscopy combined with image restoration to analyse and quantify the intracellular localisation of fluorescently labelled nanoparticles."
G.I.T. Imaging & Microscopy 2011, 5.
"Realistic exposure methods for investigating the interaction of nanoparticles with the lung at the air-liquid interface in vitro"
Insciences J. 2011, 1 (1), 30–64.
"Endocytosis of environmental and engineered micro- and nanosized particles."
Compr Physiol 2011, 1 (3), 1159–1174. [Link]
"Quantum dot cytotoxicity in vitro: An investigation into the cytotoxic effects of a series of different surface chemistries and their core/shell materials"
Nanotoxicology 2011, 5 (4), 664–674. [Link]
"State of the art toxicological and microscopic assessment of biomedical nanocrystals on the lung in vitro"
"Nanotoxicology: A perspective and discussion of whether or not in vitro testing is a valid alternative."
Arch. Toxicol. 2011, 85 (7), 723–731.
"Investigating the interaction of cellulose nanofibers derived from cotton with a sophisticated 3D human lung cell coculture."
Biomacromolecules 2011, 12 (10), 3666–3673. [Link]
"The uptake and intracellular fate of a series of different surface coated quantum dots in vitro"
Toxicology 2011, 286 (1-3), 58–68. [Link]
"Laser scanning microscopy combined with image restoration to analyse a 3D model of the human epithelial airway barrier."
Swiss Medical Weekly 2010, 140, w13060. [Link]
"A sophisticated model of the human epithelial airway barrier to study uptake, cell responses and intracellular distribution of nanoparticles"
European Cells and Materials 2010, 20 (SUPPL.3), 216.
"An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signalling in vitro."
Nanotoxicology 2010, 4 (2), 139–149. [Link]
"The effects of serum on the toxicity of manufactured nanoparticles."
Toxicol. Lett. 2010, 198 (3), 358–365. [Link]
"Intracellular imaging of nanoparticles: Is it an elemental mistake to believe what you see?"
Particle and Fibre Toxicology 2010, 7, 15. [Link]
"Nanotoxicology: A Brief Overview and Discussion of the Current Toxicological Testing In Vitro and Suggestions for Future Research"
"The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line."
Toxicology and Applied Pharmacology 2008, 232 (3), 418–427. [Link]
"Air Pollution, Ultrafine and Nanoparticle Toxicology: Cellular and Molecular Interactions"
IEEE Transactions on Nanobioscience 2007, 6 (4), 331–340.