Rothen-Rutishauser Barbara

Rothen-Rutishauser Barbara

Professor, BioNanomaterials
Adolphe Merkle Institute
Rte de l'Ancienne Papeterie, CP209
CH-1723 Marly 1
Switzerland
Phone:+41 26 300 9502
Fax:+41 26 300 9624
Email:(turn on JavaScript)

Research projects

Publications

2014

Hirsch, V.; Kinnear, C.; Rodriguez-Lorenzo, L.; Monnier, C. A.; Rothen-Rutishauser, B.; Balog, S.; Petri-Fink, A.
In Vitro Dosimetry of Agglomerates
Nanoscale 2014. [Link]

Bonnaud, C.; Monnier, C. A.; Demurtas, D.; Jud, C.; Vanhecke, D.; Montet, X.; Hovius, R.; Lattuada, M.; Rothen-Rutishauser, B.; Petri-Fink, A.
Insertion of Nanoparticle Clusters into Vesicle Bilayers
Acs Nano 2014, 8 (4), 3451–3460. [Link]

Schürch, D.; Vanhecke, D.; Clift, M. J. D.; Raemy, D.; de Aberasturi, D. J.; Parak, W. J.; Gehr, P.; Petri-Fink, A.; Rothen-Rutishauser, B.
Modeling Nanoparticle--Alveolar Epithelial Cell Interactions under Breathing Conditions Using Captive Bubble Surfactometry
Langmuir 2014, 30 (17), 4924–4932. [Link]

Steiner, S.; Heeb, N. V.; Czerwinski, J.; Comte, P.; Mayer, A. C. R.; Petri-Fink, A.; Rothen-Rutishauser, B.
Test-methods on the test-bench: A comparison of complete exhaust and exhaust particle extracts for genotoxicity/mutagenicity assessment
Environ Sci Technol. 2014, In press.

Schild, C.; Hahn, D.; Schaller, A.; Jackson, C. D.; Rothen-Rutishauser, B.; Mirkovitch, J.; Nuoffer, J. M.
Mitochondrial leucine tRNA level and PTCD1 are regulated in response to leucine starvation
Amino Acids 2014, In press.

Rodriguez-Lorenzo, L.; Fytianos, K.; Blank, F.; Von Garnier, C.; Rothen-Rutishauser, B.; Petri-Fink, A.
Encoded particles: Fluorescence-encoded gold nanoparticles: Library design and modulation of cellular uptake into dendritic cells
Small 2014, 1440. [Link]

Matho, S. K.; Tenenbaum-Katan, J.; Greenblum, A.; Rothen-Rutishauser, B.; Sznitman, J.
Microfluidic shear stress-regulated surfactant secretion in alveolar epithelial typo II cells in vitro
Am J Physiol Lung Cell Mol Physiol 2014, 672–683. [Link]

Digigow, R. G.; Dechezelles, J. F.; Kaufmann, J.; Vanhecke, D.; Knapp, H.; Lattuada, M.; Rothen-Rutishauser, B.; Petri-Fink, A.
Magnetic microreactors for efficient and reliable magnetic nanoparticles surface functionalization
Lab on a Chip 2014, In press. [Link]

Digigow, R. G.; Dechezelles, J. F.; Dietsch, H.; Geissbühler, I.; Vanhecke, D.; Geers, C.; Hirt, A. M.; Rothen-Rutishauser, B.; Petri-Fink, A.
Preparation and Characterization of Functional Silica Hybrid Magnetic Nanoparticles
Journal of Magnetism and Magnetic Materials 2014, 72–79. [Link]

2013

Steiner, S.; Czerwinski, J.; Comte, P.; Popovicheva, O.; Kireeva, E.; Muller, L.; Heeb, N.; Mayer, A.; Petri-Fink, A.; Rothen-Rutishauser, B.
Comparison of the toxicity of diesel exhaust produced by bio- and fossil diesel combustion in human lung cells in vitro
Atmospheric Environment 2013, 81, 380–388. [Link]

Clift, M. J. D.; Frey, S.; Endes, C.; Hirsch, V.; Kuhn, D. A.; Johnston, B. D.; Wick, P.; Petri-Fink, A.; Rothen-Rutishauser, B.
Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro
BioNanoMaterials 2013, 14 (3-4). [Link]

Steiner, S.; Czerwinski, J.; Comte, P.; Müller, L. L.; Heeb, N. V.; Mayer, A.; Petri-Fink, A.; Rothen-Rutishauser, B.
Reduction in (pro-)inflammatory responses of lung cells exposed in vitro to diesel exhaust treated with a non-catalyzed diesel particle filter
Atmospheric Environment 2013, 81, 117–124. [Link]

Clift, M. J. D.; Endes, C.; Vanhecke, D.; Wick, P.; Gehr, P.; Schins, R. P. F.; Petri-Fink, A.; Rothen-Rutishauser, B.
A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes.
Toxicol. Sci. 2013, 137 (1), 55–64. [Link]

Kinnear, C.; Dietsch, H.; Clift, M. J. D.; Endes, C.; Rothen-Rutishauser, B.; Petri-Fink, A.
Gold Nanorods - Controlling their Surface Chemistry and Complete Detoxification by a Two-Step Place Exchange
Angewandte Chemie Int Ed. 2013, 52(7), 1934–1938.

Jud, C.; Clift, M. J. D.; Petri-Fink, A.; Rothen-Rutishauser, B.
Nanomaterial and the human lung: What is known and what must be deciphered to realise their potential advantages?
Swiss Medical Weekly 2013, published.

Heuking, S.; Rothen-Rutishauser, B.; Raemy, D. O.; Gehr, P.; Borchard, G.
Fate of TLR-1/TLR-2 agonist functionalised pDNA nanoparticles upon deposition at the human bronchial epithelium in vitro
Journal of Nanobiotechnology 2013, 11.

Clift, M. J. D.; Endes, C.; Vanhecke, D.; Wick, P.; Schins, R. P. F.; Petri-Fink, A.; Rothen-Rutishauser, B.
Efficiency and efficacy of using a sophisiticated 3D in vitro system of the human epithelial airway barrier to gain insight into the hazard posed by nanomaterials
Toxicology Letters 2013, 146–147.

Behra, R.; Sigg, L.; Clift, M. J. D.; Herzog, F.; Minghetti, M.; Johnston, B.; Petri-Fink, A.; Rothen-Rutishauser, B.
Bioavailability of Silver-Nanoparticles and -ions: From a chemical and biochemical perspective
Journal of the Royal Society Interface 2013, 87.

Endes, C.; Mueller, S.; Schmid, O.; Vanhecke, D.; Foster, J. E.; Petri-Fink, A.; Rothen-Rutishauser, B.; Weder, C.; Clift, M. J. D.
Risk assessment of released cellulose nanocrystals-mimicking inhalatory exposure
Journal of Physics: Conference Series 2013. [Link]

Rothen-Rutishauser, B.; Kuhn, D. A.; Zulqurnain, A.; Gasser, M.; Amin, F.; Parak, W. J.; Vanhecke, D.; Petri-Fink, A.; Gehr, P.; Brandenberger, C.
Quantification of gold nanoparticle cell uptake under controlled biological conditions and adequate resolution
Nanomedicine 2013. [Link]

Muller, L.; Comte, P.; Czerwinski, J.; Kasper, M.; Mayer, A. C. R.; Gehr, P.; Burtscher, H.; Morin, J.-P.; Konstandopoulos, A.; Rothen-Rutishauser, B.
New Exposure System To Evaluate the Toxicity of (Scooter) Exhaust Emissions in Lung Cells in Vitro
Environmental Science and Technology 2013, 44 (7), 2632–2638. [Link]

Kinnear, C.; Dietsch, H.; Clift, M. J. D.; Endes, C.; Rothen-Rutishauser, B.; Petri-Fink, A.
Gold nanorods: Controlling their surface chemistry and complete detoxification by a two-step place exchange
Angewandte Chemie International Edition 2013, 52 (7), 1934–1938. [Link]

Jud, C.; Clift, M. J. D.; Petri-Fink, A.; Rothen-Rutishauser, B.
Nanomaterials and the human lung: What is known and what must be deciphered to realise their potential advantages?
Swiss Medical Weekly 2013, 143, w13758. [Link]

Hirsch, V.; Salaklang, J.; Rothen-Rutishauser, B.; Petri-Fink, A.
Influence of Serum Supplemented Cell Culture Medium on Colloidal Stability of Polymer Coated Iron Oxide and Polystyrene Nanoparticles With Impact on Cell Interactions In Vitro
IEEE Transactions on Magnetics 2013, 49 (1). [Link]

Hirsch, V.; Kinnear, C.; Moniatte, M.; Rothen-Rutishauser, B.; Clift, M. J. D.; Petri-Fink, A.
Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro
Nanoscale 2013, 5 (9), 3723–3732. [Link]

Herzog, F.; Clift, M. J. D.; Piccapietra, F.; Behra, R.; Schmid, O.; Petri-Fink, A.; Rothen-Rutishauser, B.
Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface
Particle and Fibre Toxicology 2013, 10 (1), 11. [Link]

Clift, M. J. D.; Rothen-Rutishauser, B.
Studying the oxidative stress paradigm in vitro: A theoretical and practical perspective
Methods Mol. Biol. 2013, 1028, 115–133. [Link]

Clift, M. J. D.; Raemy, D. O.; Zulqurnain, A.; Lehmann, A. D.; Brandenberger, C.; Petri-Fink, A.; Wick, P.; Parak, W. J.; Gehr, P.; Schins, R. P. F.; Rothen-Rutishauser, B.
Investigating the interaction between nano-objects and bacteria: Can it provide an insight into nano-object mutagenicity?
Nanotoxicology 2013.

Bonnaud, C.; Vanhecke, D.; Demurtas, D.; Rothen-Rutishauser, B.; Petri-Fink, A.
Spatial SPION Localization in Liposome Membranes
IEEE Transactions on Magnetics 2013, 49 (1), 166–171. [Link]

Blank, F.; Stumbles, P. A.; Seydoux, E.; Holt, P. G.; Petri-Fink, A.; Rothen-Rutishauser, B.; Strickland, D. H.; Von Garnier, C.
Size-dependent Uptake of Particles by Pulmonary APC Populations and Trafficking to Regional Lymph Nodes
American Journal of Respiratory Cell and Molecular Biology 2013. [Link]

2012

Clift, M. J. D.; Raemy, D. O.; Endes, C.; Zulqurnain, A.; Lehmann, A. D.; Brandenberger, Ch.; Petri-Fink, A.; Wick, P.; Parak, W. J.; Gehr, P.; Schins, R. P. F.; Rothen-Rutishauser, B.
Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria
Nanotoxicology 2012, 1–12.

Steiner, S.; Müller, L.; Popovicheva, O. B.; Raemy, D. O.; Czerwinski, J.; Comte, P.; Mayer, A. C. R.; Gehr, P.; Rothen-Rutishauser, B.; Clift, M. J. D.
Cerium dioxide nanoparticles can interfere with the associated cellular mechanistic response to diesel exhaust exposure
Tox Letters 2012, 2012 (2), 218–225. [Link]

Schleh, C.; Rothen-Rutishauser, B.; Blank, F.; Lauenstein, H. D.; Nassimi, M.; Krug, N.; Braun, A.; Erpenbeck, B. J.; Gehr, P.; Hohfeld, J. M.
Surfactant Protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
Respiratory Research 2012, 13, 8. [Link]

Rivera-Gil, P.; Clift, M. J. D.; Rothen-Rutishauser, B.; Parak, W. J.
Methods for understanding the interaction between nanoparticles and cells
Methods Mol Biol 2012, 926, 22–56. [Link]

Petri-Fink, A.; Rothen-Rutishauser, B.
Nanoparticles and Cells: An Interdisciplinary Approach
Chimia 2012, 66 (3), 104–109. [Link]

Peeter, S.; Kitz, M.; Preisser, S.; Wetterwald, A.; Rothen-Rutishauser, B.; Thalmann, G. n.; Brandenberger, C.; Bailey, A.; Frenz, M.
Mechanisms of nanoparticle-mediated photomechanical cell damage
Biomed Opt Express 2012, 3 (3), 435–446. [Link]

Müller, L.; Comte, P.; Czerwinski, J.; Kasper, M.; Mayer, A. C. R.; Schmid, A.; Rosinus, L.; Clift, M. J. D.; Steiner, S.; Gehr, P.; Rothen-Rutishauser, B.
Investigating the potential for different scooter and car exhaust emissions to cause cytotoxic and (pro-)inflammatory responses to a 3D in vitro model of the human epithelial airway
Tox Env. Chem. 2012, 94 (1), 164–180. [Link]

Muehlfeld, C.; Poland, D. A.; Duffin, R.; Brandenberger, C.; Murphy, A. F.; Rothen-Rutishauser, B.; Gehr, P.; Donaldson, K.
Differential effects of long and short carbon nanotubes on the gas-exchange region of the mouse lung
Nanotoxicology 2012, 6, 687–679. [Link]

Mahmoudi, M.; Saeedi-Eslami, S. N.; Shokrgozar, M. A.; Azadmanesh, K.; Hasanloo, M.; Kalhor, H.; Burtea, C.; Rothen-Rutishauser, B.; Laurent, S.; Sheibani, S.; Vali, H.
Cell 'vision': Complementary Factor of Protein Corona in NanoToxicology
Nanoscale 2012, 4 (17), 5461–5468. [Link]

Mahmoudi, M.; Hofmann, H.; Rothen-Rutishauser, B.; Petri-Fink, A.
Assessing the In Vitro and In Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles
Chem. Rev. 2012, 112 (4), 2323–2338. [Link]

Gasser, M.; Wick, P.; Clift, M. J. D.; Blank, F.; Diener, L.; Yan, B.; Gehr, P.; Krug, H. F.; Rothen-Rutishauser, B.
Pulmonary surfactant coating of multi-walled carbon nanotubes (MWCNTs) influences their oxidative and pro-inflammatory potential in vitro
Particle and Fibre Toxicology 2012, 9, 9:17. [Link]

Desplantez, T.; McCain, M. L.; Beauchamp, P.; Rigoli, G.; Rothen-Rutishauser, B.; Parker, K. K.; Kleber, A. G.
Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current
Cardiovasc Res 2012, 94 (1), 58–65. [Link]

Ahmad, S.; Raemy, D. O.; Loader, J. E.; Kailey, J. M.; Neeves, K. B.; White, C. W.; Ahmad, A.; Gehr, P.; Rothen-Rutishauser, B.
Interaction and localization of synthetic nanoparticles in healthy and cystic fibrosis airway epithelial cells: Effect of ozone exposure
J. Aerosol Med Pulm Drug Deliv. 2012, 25 (1), 7–15. [Link]

Rothen-Rutishauser, B.; Clift, M. J. D.; Jud, C.; Petri-Fink, A.; Wick, P.
Human epithelial cells in vitro – Are they an advantageous tool to help understand the nanomaterial-biological barrier interaction?
EuroNanoToxLetters 2012, 4 (1), 1–20. [Link]

Raemy, D. O.; Grass, R. N.; Stark, W. J.; Schumacher, C. M.; Clift, M. J. D.; Gehr, P.; Rothen-Rutishauser, B.
Effects of flame made zinc oxide particles in human lung cells - a comparison of aerosol and suspension exposures.
Particle and Fibre Toxicology 2012, 9, 33. [Link]

McCain, M. L.; Desplantez, T.; Geisse, N. A.; Rothen-Rutishauser, B.; Oberer, H.; Parker, K. K.; Kleber, A. G.
Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: Relation between Cx43 immunofluorescence and intercellular electrical conductance.
Am. J. Physiol. Heart Circ. Physiol. 2012, 302 (2), H443–H450. [Link]

Könczöl, M.; Goldenberg, E.; Ebeling, S.; Schäfer, B.; Garcia-Käufer, M.; Gminski, R.; Grobéty, B.; Rothen-Rutishauser, B.; Merfort, I.; Gieré, R.; Mersch-Sundermann, V.
Cellular uptake and toxic effects of fine and ultrafine metal-sulfate particles in human A549 lung epithelial cells.
Chem. Res. Toxicol. 2012, 25 (12), 2687–2703. [Link]

Griffete, N.; Clift, M. J. D.; Lamouri, A.; Digigow, R. G.; Mihut, A. M.; Petri-Fink, A.; Rothen-Rutishauser, B.; Dietsch, H.
Amino covalent binding approach on iron oxide nanoparticle surface: Toward biological applications
Colloids and Surfaces A: Physicochemical and Engineering Aspects 2012, 415, 98–104. [Link]

Clift, M. J. D.; Raemy, D. O.; Endes, C.; Zulqurnain, A.; Lehmann, A. D.; Brandenberger, C.; Petri-Fink, A.; Wick, P.; Parak, W. J.; Gehr, P.; Schins, R. P. F.; Rothen-Rutishauser, B.
Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria.
Nanotoxicology 2012. [Link]

2011

Wick, P.; Clift, M. J. D.; Rösslein, M.; Rothen-Rutishauser, B.
A brief summary of carbon nanotubes science and technology: A health and safety perspective.
ChemSusChem 2011, 4 (7), 905–911. [Link]

Thurnherr, T. A.; Brandenberger, C. B.; Fischer, K. A.; Diener, L. A.; Manser, P. A.; Maeder-Althaus, X. A.; Kaiser, J. P. A.; Krug, H. F. A.; Rothen-Rutishauser, B.; Wick, P.
A comparison of acute and long-term effects of industrial multiwalled carbon nanotubes on human lung and immune cells in vitro
Toxicol. Lett. 2011, 200 (3), 176–186. [Link]

Schleh, C.; Rothen-Rutishauser, B.; Kreyling, W. G.
The influence of pulmonary surfactant on nanoparticulate drug delivery systems
Biological Barriers A Need for Novel Tools in Nanotoxicology and Nanomedicine The 8th International Conference and Workshop - Biological Barriers - in vitro Tools in Nanotoxicology and Nanomedicine 2011, 77 (3), 350–352. [Link]

Rothen-Rutishauser, B.; Blank, F.; Petri-Fink, A.; Clift, M. J. D.; Geiser, T.; Von Garnier, C.
Laser scanning microscopy combined with image restoration to analyse and quantify the intracellular localisation of fluorescently labelled nanoparticles.
G.I.T. Imaging & Microscopy 2011, 5.

Raemy, D. O.; Limbach, L. K.; Rothen-Rutishauser, B.; Grass, R. N.; Gehr, P.; Birbaum, K.; Brandenberger, C.; Günther, D.; Stark, W. J.
Cerium oxide nanoparticle uptake kinetics from the gas-phase into lung cells in vitro is transport limited
Biological Barriers A Need for Novel Tools in Nanotoxicology and Nanomedicine The 8th International Conference and Workshop - Biological Barriers - in vitro Tools in Nanotoxicology and Nanomedicine 2011, 77 (3), 368–375. [Link]

Paur, H.-R.; Cassee, F. R.; Teeguarden, J.; Fissan, H.; Diabate, S.; Aufderheide, M.; Kreyling, W. G.; Hänninen, O.; Kasper, G.; Riediker, M.; Rothen-Rutishauser, B.; Schmid, O.
In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung—A dialog between aerosol science and biology
Journal of Aerosol Science 2011, 42 (10), 668–692. [Link]

Muller, L.; Gasser, M.; Raemy, D. O.; Herzog, F.; Brandenberger, C.; Schmid, O.; Gehr, P.; Rothen-Rutishauser, B.; Clift, M. J. D.
Realistic exposure methods for investigating the interaction of nanoparticles with the lung at the air-liquid interface in vitro
Insciences J. 2011, 1 (1), 30–64.

Lehmann, A. D.; Daum, N.; Bur, M.; Lehr, C.-M.; Gehr, P.; Rothen-Rutishauser, B.
An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier.
Eur J Pharm Biopharm 2011, 77 (3), 398–406. [Link]

Könczöl, M.; Ebeling, S.; Goldenberg, E.; Treude, F.; Gminski, R.; Gieré, R.; Grobéty, B.; Rothen-Rutishauser, B.; Merfort, I.; Mersch-Sundermann, V.
Cytotoxicity and genotoxicity of size-fractionated iron oxide (magnetite) in A549 human lung epithelial cells: Role of ROS, JNK, and NF-κB.
Chem. Res. Toxicol. 2011, 24 (9), 1460–1475. [Link]

Gehr, P.; Clift, M. J. D.; Brandenberger, C.; Lehmann, A.; Herzog, F.; Rothen-Rutishauser, B.
Endocytosis of environmental and engineered micro- and nanosized particles.
Compr Physiol 2011, 1 (3), 1159–1174. [Link]

Frick, R.; Müller-Edenborn, B.; Schlicker, A.; Rothen-Rutishauser, B.; Raemy, D. O.; Günther, D.; Hattendorf, B.; Stark, W.; Beck-Schimmer, B.
Comparison of manganese oxide nanoparticles and manganese sulfate with regard to oxidative stress, uptake and apoptosis in alveolar epithelial cells.
Toxicol. Lett. 2011, 205 (2), 163–172. [Link]

Clift, M. J. D.; Varet, J.; Hankin, S. M.; Brownlee, B.; Davidson, A. M.; Brandenberger, C.; Rothen-Rutishauser, B.; Brown, D. M.; Stone, V.
Quantum dot cytotoxicity in vitro: An investigation into the cytotoxic effects of a series of different surface chemistries and their core/shell materials
Nanotoxicology 2011, 5 (4), 664–674. [Link]

Clift, M. J. D.; Gehr, P.; Rothen-Rutishauser, B.
State of the art toxicological and microscopic assessment of biomedical nanocrystals on the lung in vitro
2011. [Link]

Clift, M. J. D.; Gehr, P.; Rothen-Rutishauser, B.
Nanotoxicology: A perspective and discussion of whether or not in vitro testing is a valid alternative.
Arch. Toxicol. 2011, 85 (7), 723–731.

Clift, M. J. D.; Foster, J. E.; Vanhecke, D.; Studer, D.; Wick, P.; Gehr, P.; Rothen-Rutishauser, B.; Weder, C.
Investigating the interaction of cellulose nanofibers derived from cotton with a sophisticated 3D human lung cell coculture.
Biomacromolecules 2011, 12 (10), 3666–3673. [Link]

Clift, M. J. D.; Brandenberger, C.; Rothen-Rutishauser, B.; Brown, D. M.; Stone, V.
The uptake and intracellular fate of a series of different surface coated quantum dots in vitro
Toxicology 2011, 286 (1-3), 58–68. [Link]

Blank, F.; Wehrli, M.; Lehmann, A.; Baum, O.; Gehr, P.; Von Garnier, C.; Rothen-Rutishauser, B.
Macrophages and dendritic cells express tight junction proteins and exchange particles in an in vitro model of the human airway wall.
Immunobiology 2011, 216 (1-2), 86–95. [Link]

Blank, F.; Gerber, P.; Rothen-Rutishauser, B.; Sakulkhu, U.; Salaklang, J.; De Peyer, K.; Gehr, P.; Nicod, L. P.; Hofmann, H.; Geiser, T.; Petri-Fink, A.; Von Garnier, C.
Biomedical nanoparticles modulate specific CD4+ T cell stimulation by inhibition of antigen processing in dendritic cells
Nanotoxicology 2011, 5 (4), 606–621. [Link]

2010

Rothen-Rutishauser, B.; Lehmann, A. D.; Clift, M. J. D.; Blank, F.; Gehr, P.
Laser scanning microscopy combined with image restoration to analyse a 3D model of the human epithelial airway barrier.
Swiss Medical Weekly 2010, 140, w13060. [Link]

Rothen-Rutishauser, B.; Clift, M. J. D.; Brandenberger, C.; Lehmann, A.; Müller, L.; Raemy, D.; Gehr, P.
A sophisticated model of the human epithelial airway barrier to study uptake, cell responses and intracellular distribution of nanoparticles
European Cells and Materials 2010, 20 (SUPPL.3), 216.

Rothen-Rutishauser, B.; Brown, D. M.; Piallier-Boyles, M.; Kinloch, I. A.; Windle, A. H.; Gehr, P.; Stone, V.
Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivity in vitro and inflammation in vivo.
Nanotoxicology 2010, 4 (3), 331–342. [Link]

Muller, L.; Riediker, M.; Wick, P.; Mohr, M.; Gehr, P.; Rothen-Rutishauser, B.
Oxidative stress and inflammation response after nanoparticle exposure: Differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways.
J. R. Soc. Interface 2010, 7 Suppl 1, S27–40. [Link]

Maina, J. N.; West, J. B.; Orgeig, S.; Foot, N. J.; Daniels, C. B.; Kiama, S. G.; Gehr, P.; Muehlfeld, C.; Blank, F.; Müller, L.; Lehmann, A.; Brandenberger, C.; Rothen-Rutishauser, B.
Recent advances into understanding some aspects of the structure and function of mammalian and avian lungs.
Physiol Biochem Zool 2010, 83 (5), 792–807. [Link]

Lehmann, A. D.; Parak, W. J.; Zhang, F.; Zulqurnain, A.; Rocker, C.; Nienhaus, G. U.; Gehr, P.; Rothen-Rutishauser, B.
Fluorescent-magnetic hybrid nanoparticles induce a dose-dependent increase in proinflammatory response in lung cells in vitro correlated with intracellular localization.
Small 2010, 6 (6), 753–762. [Link]

Gasser, M.; Rothen-Rutishauser, B.; Krug, H. F.; Gehr, P.; Nelle, M.; Yan, B.; Wick, P.
The adsorption of biomolecules to multi-walled carbon nanotubes is influenced by both pulmonary surfactant lipids and surface chemistry.
J Nanobiotechnology 2010, 8, 31. [Link]

Brandenberger, C.; Rothen-Rutishauser, B.; Muehlfeld, C.; Schmid, O.; Ferron, G. A.; Maier, K. L.; Gehr, P.; Lenz, A.-G.
Effects and uptake of gold nanoparticles deposited at the air-liquid interface of a human epithelial airway model.
Toxicology and Applied Pharmacology 2010, 242 (1), 56–65. [Link]

Brandenberger, C.; Muehlfeld, C.; Zulqurnain, A.; Lenz, A.-G.; Schmid, O.; Parak, W. J.; Gehr, P.; Rothen-Rutishauser, B.
Quantitative evaluation of cellular uptake and trafficking of plain and polyethylene glycol-coated gold nanoparticles.
Small 2010, 6 (15), 1669–1678. [Link]

Brandenberger, C.; Clift, M. J. D.; Vanhecke, D.; Muehlfeld, C.; Stone, V.; Gehr, P.; Rothen-Rutishauser, B.
Intracellular imaging of nanoparticles: Is it an elemental mistake to believe what you see?
Particle and Fibre Toxicology 2010, 7, 15. [Link]

Berntsen, P.; Park, C. Y.; Rothen-Rutishauser, B.; Tsuda, A.; Sager, T. M.; Molina, R. M.; Donaghey, T. C.; Alencar, A. M.; Kasahara, D. I.; Ericsson, T.; Millet, E. J.; Swenson, J.; Tschumperlin, D. J.; Butler, J. P.; Brain, J. D.; Fredberg, J. J.; Gehr, P.; Zhou, E. H.
Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells.
J. R. Soc. Interface 2010, 7 Suppl 3, S331–40. [Link]

2009

Rothen-Rutishauser, B.; Grass, R. N.; Blank, F.; Limbach, L. K.; Muehlfeld, C.; Brandenberger, C.; Raemy, D. O.; Gehr, P.; Stark, W. J.
Direct combination of nanoparticle fabrication and exposure to lung cell cultures in a closed setup as a method to simulate accidental nanoparticle exposure of humans.
Environmental Science and Technology 2009, 43 (7), 2634–2640. [Link]

Obregon, C.; Rothen-Rutishauser, B.; Gerber, P.; Gehr, P.; Nicod, L. P.
Active uptake of dendritic cell-derived exovesicles by epithelial cells induces the release of inflammatory mediators through a TNF-alpha-mediated pathway.
Am J Pathol 2009, 175 (2), 696–705. [Link]

Lenz, A.-G.; Karg, E.; Lentner, B.; Dittrich, V.; Brandenberger, C.; Rothen-Rutishauser, B.; Schulz, H.; Ferron, G. A.; Schmid, O.
A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles.
Particle and Fibre Toxicology 2009, 6, 32. [Link]

Hofer, U.; Lehmann, A. D.; Waelti, E.; Amacker, M.; Gehr, P.; Rothen-Rutishauser, B.
Virosomes can enter cells by non-phagocytic mechanisms
Journal of Liposome Research 2009, 19 (4), 301–309. [Link]

Gasser, M.; Riediker, M.; Mueller, L.; Perrenoud, A.; Blank, F.; Gehr, P.; Rothen-Rutishauser, B.
Toxic effects of brake wear particles on epithelial lung cells in vitro.
Particle and Fibre Toxicology 2009, 6, 30. [Link]

Clift, M. J. D.; Blank, F.; Gehr, P.; Rothen-Rutishauser, B.
Nanotoxicology: A Brief Overview and Discussion of the Current Toxicological Testing In Vitro and Suggestions for Future Research
2009. [Link]

Bur, M.; Rothen-Rutishauser, B.; Huwer, H.; Lehr, C.-M.
A novel cell compatible impingement system to study in vitro drug absorption from dry powder aerosol formulations.
Eur J Pharm Biopharm 2009, 72 (2), 350–357. [Link]

Brandenberger, C.; Rothen-Rutishauser, B.; Blank, F.; Gehr, P.; Muehlfeld, C.
Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose.
Respir. Res. 2009, 10, 22. [Link]

2008

Rothen-Rutishauser, B.; Mueller, L.; Blank, F.; Brandenberger, C.; Muehlfeld, C.; Gehr, P.
A newly developed in vitro model of the human epithelial airway barrier to study the toxic potential of nanoparticles.
Altex 2008, 25 (3), 191–196. [Link]

Rothen-Rutishauser, B.; Blank, F.; Muehlfeld, C.; Gehr, P.
In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter.
Expert Opinion on Drug Metabolism and Toxicology 2008, 4 (8), 1075–1089. [Link]

Muehlfeld, C.; Rothen-Rutishauser, B.; Blank, F.; Vanhecke, D.; Ochs, M.; Gehr, P.
Interactions of nanoparticles with pulmonary structures and cellular responses.
Am.J.Physiol Lung Cell Mol.Physiol 2008, 294 (5), L817–29. [Link]

Muehlfeld, C.; Gehr, P.; Rothen-Rutishauser, B.
Translocation and cellular entering mechanisms of nanoparticles in the respiratory tract
Swiss Medical Weekly 2008. [Link]

Helfenstein, M.; Miragoli, M.; Rohr, S.; Muller, L.; Wick, P.; Mohr, M.; Gehr, P.; Rothen-Rutishauser, B.
Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro.
Toxicology 2008, 253 (1-3), 70–78. [Link]

Ganapathipillai, S. S.; Medova, M.; Aebersold, D. M.; Manley, P. W.; Berthou, S.; Streit, B.; Blank-Liss, W.; Greiner, R. H.; Rothen-Rutishauser, B.; Zimmer, Y.
Coupling of mutated Met variants to DNA repair via Abl and Rad51.
Cancer Research 2008, 68 (14), 5769–5777. [Link]

Clift, M. J. D.; Rothen-Rutishauser, B.; Brown, D. M.; Duffin, R.; Donaldson, K.; Proudfoot, L.; Guy, K.; Stone, V.
The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line.
Toxicology and Applied Pharmacology 2008, 232 (3), 418–427. [Link]

Blank, F.; Wehrli, M.; Baum, O.; Gehr, P.; Rothen-Rutishauser, B.
The epithelial integrity is preserved during particle exchange across the epithelium by macrophages and dendritic cells
European Respiratory Review 2008, 17 (108), 78–80. [Link]

Blank, F.; Von Garnier, C.; Obregon, C.; Rothen-Rutishauser, B.; Gehr, P.; Nicod, L. P.
Role of dendritic cells in the lung: In vitro models, animal models and human studies.
Expert Review of Respiratory Medicine 2008, 2 (2), 215–233. [Link]

2007

Rothen-Rutishauser, B.; Muehlfeld, C.; Blank, F.; Musso, C.; Gehr, P.
Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model
Particle and Fibre Toxicology 2007, 4. [Link]

Muehlfeld, C.; Mayhew, T. M.; Gehr, P.; Rothen-Rutishauser, B.
A novel quantitative method for analyzing the distributions of nanoparticles between different tissue and intracellular compartments.
J Aerosol Med 2007, 20 (4), 395–407. [Link]

Muehlfeld, C.; Geiser, M.; Kapp, N.; Gehr, P.; Rothen-Rutishauser, B.
Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the 'relative deposition index': Evidence for clearance through microvasculature.
Particle and Fibre Toxicology 2007, 4, 7. [Link]

Marquis, J.; Meyer, K.; Angehrn, L.; Kampfer, S. S.; Rothen-Rutishauser, B.; Schumperli, D.
Spinal muscular atrophy: SMN2 pre-mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence.
Mol Ther 2007, 15 (8), 1479–1486. [Link]

Blank, F.; Rothen-Rutishauser, B.; Gehr, P.
Dendritic cells and macrophages form a transepithelial network against foreign particulate antigens.
American Journal of Respiratory Cell and Molecular Biology 2007, 36 (6), 669–677. [Link]

2006

Rothen-Rutishauser, B.; Schurch, S.; Haenni, B.; Kapp, N.; Gehr, P.
Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques.
Environmental Science and Technology 2006, 40 (14), 4353–4359. [Link]

Peters, A.; Veronesi, B.; Calderón-Garcidueñas, L.; Gehr, P.; Chen, L. C.; Geiser, M.; Reed, W.; Rothen-Rutishauser, B.; Schurch, S.; Schulz, H.
Translocation and potential neurological effects of fine and ultrafine particles a critical update.
Particle and Fibre Toxicology 2006, 3, 13. [Link]

Obregon, C.; Rothen-Rutishauser, B.; Gitahi, S. K.; Gehr, P.; Nicod, L. P.
Exovesicles from human activated dendritic cells fuse with resting dendritic cells, allowing them to present alloantigens.
Am J Pathol 2006, 169 (6), 2127–2136. [Link]

Blank, F.; Rothen-Rutishauser, B.; Schurch, S.; Gehr, P.
An optimized in vitro model of the respiratory tract wall to study particle cell interactions.
J Aerosol Med 2006, 19 (3), 392–405. [Link]

2005

Wockel, A.; Baum, O.; Planitzer, G.; Rothen-Rutishauser, B.; Gossrau, R.; Abou-Dakn, M.
Constitutive coexpression of nitric oxide synthase-1 and soluble guanylyl cyclase in myoepithelial cells of mammary glands in mice.
Cells Tissues.Organs 2005, 180 (3), 178–184. [Link]

Rothen-Rutishauser, B.; Kiama, S. C.; Gehr, P.
A three-dimensional cellular model of the human respiratory tract to study the interaction with particles
American Journal of Respiratory Cell and Molecular Biology 2005, 32 (4), 281–289. [Link]

Geiser, M.; Rothen-Rutishauser, B.; Kapp, N.; Schurch, S.; Kreyling, W.; Schulz, H.; Semmler, M.; Im Hof, V.; Heyder, J.; Gehr, P.
Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells.
Environmental Health Perspectives 2005, 113 (11), 1555–1560. [Link]

2002

Waelti, E.; Wegmann, N.; Schwaninger, R.; Wetterwald, A.; Wingenfeld, C.; Rothen-Rutishauser, B.; Gimmi, C. D.
Targeting HER-2/neu with antirat neu virosomes for cancer therapy
Cancer Research 2002, 62 (2), 437–444. [Link]

Rothen-Rutishauser, B.; Riesen, F. K.; Braun, A.; Günthert, M.; Wunderli-Allenspach, H.
Dynamics of tight and adherens junctions under EGTA treatment
Journal of Membrane Biology 2002, 188 (2), 151–162. [Link]

Riesen, F. K.; Rothen-Rutishauser, B.; Wunderli-Allenspach, H.
A ZO1-GFP fusion protein to study the dynamics of tight junctions in living cells.
Histochemistry and Cell Biology 2002, 117 (4), 307–315. [Link]

Pietzonka, P.; Rothen-Rutishauser, B.; Langguth, P.; Wunderli-Allenspach, H.; Walter, E.; Merkle, H. P.
Transfer of lipophilic markers from PLGA and polystyrene nanoparticles to caco-2 monolayers mimics particle uptake.
Pharmaceutical Research 2002, 19 (5), 595–601. [Link]

Halter, W. E.; Pettke, T.; Heinrich, C. A.; Rothen-Rutishauser, B.
Major to trace element analysis of melt inclusions by laser-ablation ICP-MS: Methods of quantification
Melt Inclusions at the Millennium: Toward a Deeper Understanding of Magmatic Processes 2002, 183 (1–4), 63–86. [Link]

Drexler, H. G.; Quentmeier, H.; Dirks, W. G.; MacLeod, R. A. F.; Suda, K.; Rothen-Rutishauser, B.; Günthert, M.; Wunderli-Allenspach, H.
Bladder carcinoma cell line ECV304 is not a model system for endothelial cells (multiple letters)
In Vitro Cellular and Developmental Biology - Animal 2002, 38 (4), 185–187.

2001

Thiele, L.; Rothen-Rutishauser, B.; Jilek, S.; Wunderli-Allenspach, H.; Merkle, H. P.; Walter, E.
Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages?
Journal of Controlled Release 2001, 76 (1-2), 59–71. [Link]

Suda, K.; Rothen-Rutishauser, B.; Günthert, M.; Wunderli-Allenspach, H.
Phenotypic characterization of human umbilical vein endothelial (ECV304) and urinary carcinoma (T24) cells: Endothelial versus epithelial features
In Vitro Cellular and Developmental Biology - Animal 2001, 37 (8), 505–514. [Link]

Langer, M.; Kratz, F.; Rothen-Rutishauser, B.; Wunderli-Allenspach, H.; Beck-Sickinger, A. G.
Novel peptide conjugates for tumor-specific chemotherapy.
J. Med. Chem. 2001, 44 (9), 1341–1348. [Link]

Beyer, U.; Rothen-Rutishauser, B.; Unger, C.; Wunderli-Allenspach, H.; Kratz, F.
Differences in the intracellular distribution of acid-sensitive doxorubicin-protein conjugates in comparison to free and liposomal formulated doxorubicin as shown by confocal microscopy
Pharmaceutical Research 2001, 18 (1), 29–38. [Link]

2000

Rothen-Rutishauser, B.; Messerli, M. J.; Van Der Voort, H.; Günthert, M.; Wunderli-Allenspach, H.
Deconvolution combined with digital colocalization analysis to study the spatial distribution of tight and adherens junction proteins
Journal of Computer-Assisted Microscopy 2000, 10 (3), 103–111. [Link]

Rothen-Rutishauser, B.; Braun, A.; Günthert, M.; Wunderli-Allenspach, H.
Formation of multilayers in the Caco-2 cell culture model: A confocal laser scanning microscopy study
Pharmaceutical Research 2000, 17 (4), 460–465. [Link]

Hammerle, S. P.; Rothen-Rutishauser, B.; Krämer, S. D.; Günthert, M.; Wunderli-Allenspach, H.
P-Glycoprotein in cell cultures: A combined approach to study expression, localisation, and functionality in the confocal microscope.
Eur.J.Pharm.Sci. 2000, 12 (1), 69–77. [Link]

Fabry, M.; Langer, M.; Rothen-Rutishauser, B.; Wunderli-Allenspach, H.; Hocker, H.; Beck-Sickinger, A. G.
Monitoring of the internalization of neuropeptide Y on neuroblastoma cell line SK-N-MC.
Eur J Biochem 2000, 267 (17), 5631–5637. [Link]

Cattaneo-Pangrazzi, R. M.; Schott, H.; Wunderli-Allenspach, H.; Rothen-Rutishauser, B.; Guenthert, M.; Schwendener, R. A.
Cell-cycle arrest and p53-independent induction of apoptosis in vitro by the new anticancer drugs 5-FdUrd-P-FdCydOct and dCydPam-P-FdUrd in DU-145 human prostate cancer cells.
Journal of Cancer Research and Clinical Oncology 2000, 126 (5), 247–256. [Link]

Braun, A.; Hämmerle, S.; Suda, K.; Rothen-Rutishauser, B.; Günthert, M.; Krämer, S. D.; Wunderli-Allenspach, H.
Cell cultures as tools in biopharmacy
Eur.J.Pharm.Sci. 2000, 11 (SUPPL. 2), S51–S60. [Link]

1999

Thiele, L.; Rothen-Rutishauser, B.; Wunderli-Allenspach, H.; Merkle, H. P.; Walter, E.
Particle-uptake by monocyte-derived dendritic cells in vitro: Evaluation of particle size and surface characteristics
Proceedings of the Controlled Release Society 1999 (26), 163–164.

Pietzonka, P.; Rothen-Rutishauser, B.; Walter, E.; Langguth, P.; Wunderli-Allenspach, H.; Merkle, H. P.
Particle uptake by the Caco-2 monolayer model: Fact or fiction?
Proceedings of the Controlled Release Society 1999 (26), 925–926.

Hsu, C. P.; Walter, E.; Merkle, H. P.; Rothen-Rutishauser, B.; Wunderli-Allenspach, H.; Hilfinger, J. M.; Amidon, G. L.
Function and immunolocalization of overexpressed human intestinal H+/peptide cotransporter in adenovirus-transduced Caco-2 cells.
AAPS PharmSci 1999, 1 (3), E12. [Link]

1998

Schmidt, M. C.; Rothen-Rutishauser, B.; Rist, B.; Beck-Sickinger, A.; Wunderli-Allenspach, H.; Rubas, W.; Sadee, W.; Merkle, H. P.
Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane.
Biochemistry 1998, 37 (47), 16582–16590. [Link]

Rothen-Rutishauser, B.; Krämer, S.; Braun, A.; Günthert, M.; Wunderli-Allenspach, H.
MDCK Cell Cultures as an Epithelial In Vitro Model: Cytoskeleton and Tight Junctions as Indicators for the Definition of Age-Related Stages by Confocal Microscopy
Pharmaceutical Research 1998, 15 (7), 964-971-971. [Link]

Rothen-Rutishauser, B.; Ehler, E.; Perriard, E.; Messerli, J. M.; Perriard, J. C.
Different behaviour of the non-sarcomeric cytoskeleton in neonatal and adult rat cardiomyocytes.
Journal of Molecular and Cellular Cardiology 1998, 30 (1), 19–31. [Link]

Lang, S.; Rothen-Rutishauser, B.; Perriard, J. C.; Schmidt, M. C.; Merkle, H. P.
Permeation and pathways of human calcitonin (hCT) across excised bovine nasal mucosa.
Peptides 1998, 19 (3), 599–607. [Link]

1997

Lang, V. B.; Langguth, P.; Ottiger, C.; Wunderli-Allenspach, H.; Rognan, D.; Rothen-Rutishauser, B.; Perriard, J. C.; Lang, S.; Biber, J.; Merkle, H. P.
Structure-permeation relations of met-enkephalin peptide analogues on absorption and secretion mechanisms in Caco-2 monolayers.
Journal of Pharmaceutical Sciences 1997, 86 (7), 846–853. [Link]

1996

Kaldis, P.; Stolz, M.; Wyss, M.; Zanolla, E.; Rothen-Rutishauser, B.; Vorherr, T.; Wallimann, T.
Identification of two distinctly localized mitochondrial creatine kinase isoenzymes in spermatozoa.
J. Cell. Sci. 1996, 109 ( Pt 8), 2079–2088. [Link]

1995

Kraft, T.; Messerli, M.; Rothen-Rutishauser, B.; Perriard, J. C.; Wallimann, T.; Brenner, B.
Equilibration and exchange of fluorescently labeled molecules in skinned skeletal muscle fibers visualized by confocal microscopy
Biophysical Journal 1995, 69 (4), 1246–1258. [Link]

Bohner, V.; Rothen-Rutishauser, B.; Perriard, J. C.; Ottiger, C.; Wunderli-Allenspach, H.; Merkle, H. P.; Langguth, P.
Intestinal transport mechanism of peptides across Caco-2 cell monolayers and visualization by confocal laser scanning microscopy
Proceedings of the Controlled Release Society 1995 (22), 540–541.

Endes, C.; Schmid, O.; Kinnear, C.; Muller, S.; Camarero Espinosa, S.; Banhecke, D.; Foster, J. E.; Petri-Fink, A.; Rothen-Rutishauser, B.; Weder, C.; Clift, M. J. D.
A systematic in vitro approach towards mimicking the inhalation of high aspect ratio nanoparticles
, submitted.

Adolphe Merkle Institute - Rte de l'Ancienne Papeterie CP 209 - CH-1723 Marly 1 - Phone +41 26 300 9254 - Fax +41 26 300 9624